Many individuals and their physicians have used alternative dosing regimens outside those recommended by the FDA. These include biweekly dosing at 120 mg/kg, dosing every third week at 180 mg/kg, and monthly dosing at 250 mg/kg. While these regimens have been used for years, some evidence suggests that weekly dosing at 60 mg/kg is the most effective. Most Alpha-1 aware physicians limit the use of more extended dosing intervals to individuals with significant logistical problems that make weekly dosing a hardship.
Even in these individuals, if lung function decline seems to remain accelerated or if side effects become a problem, it is wise to consider switching to the weekly dosing regimen to determine if this helps to alleviate the individual’s problems.Augmentation Therapy – AlphaNet