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Who should be tested for Alpha-1?

  • Newborns, children, and adults with unexplained liver disease
  • People with a family history of liver disease
  • Relatives of a person diagnosed with Alpha-1
  • Everyone with emphysema, bronchiectasis, chronic obstructive pulmonary disease (COPD), chronic bronchitis, or asthma that is incompletely reversible after aggressive treatment

The Liver and Alpha-1 Antitrypsin DeficiencyAlpha-1 Foundation

Until it is appropriate to begin screening the general population for Alpha-1, there are some guidelines as to who should be tested for this condition. These include individuals with:

  • All individuals with a diagnosis of emphysema, chronic bronchitis, unexplained bronchiectasis, or chronic obstructive pulmonary disease (COPD)
  • Family history of Alpha-1
  • Family history of emphysema, bronchiectasis, liver disease, or panniculitis
  • Chronic asthma in which lung function does not return to normal with therapy in adolescents and adults
  • Recurrent pneumonia or bronchitis
  • Unexplained liver disease
  • Granulomatosis with polyangiitis (GPA or C-ANCA positive vasculitis)
  • Necrotizing panniculitis
Big Fat Reference Guide – AlphaNet