It is recommended that nonsteroidal anti-inflammatory drugs (NSAIDS) not be used on children with Alpha-1. These drugs including aspirin, ibuprofen and naproxen have shown in animal studies to be highly toxic to the liver and kidneys. This is a general caution, but not an absolute recommendation of avoidance as the data in humans is not fully clear. Acetaminophen, such as Tylenol, is a miscellaneous analgesic for mild to moderate pain or fever and is safe to take in ordinary doses.
Alpha-1-To-One, Winter 2021 – Alpha-1 Foundation