Individuals receiving these drugs never have any significant problems. In the more than 30-year experience with Prolastin, the most common side effect is a sense of feeling drained or having flu-like symptoms that typically last for up to 24 hours following an infusion. These types of symptoms can often be reduced or eliminated by slowing the rate of infusion. Some patients have symptoms that are suggestive of mild allergic reactions consisting of hives, itching, tightness in the chest, shortness of breath, and/or wheezing. Many of these patients can continue receiving augmentation therapy if they are pretreated with an antihistamine, such as Benadryl, prior to their infusions. On rare occasions, side effects are severe enough to cause individuals to stop augmentation therapy entirely.
Published experience with all of the augmentation products is insufficient to know whether switching to a different brand of augmentation therapy will be helpful for those who experience side effects on a particular brand of therapy. It is likely this will be a successful option for some people. Individuals who develop severe systemic reactions to one form of augmentation therapy should be monitored extremely closely if they are to be switched to another augmentation therapy. In clinical trials, the newer products demonstrated rates of side effects similar to Prolastin.Are there any side effects associated with augmentation therapy? – Big Fat Reference Guide