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MF

People with this genotype do not have alpha-1 antitrypsin deficiency but are genetic carriers of one mutation.
Because Alpha-1 is a genetic condition, your result means that your relatives are at increased risk to have AATD or carry abnormal alpha-1 genes. We encourage you to make your family members and any reproductive partner aware of the condition in your family and the availability of testing.

Alpha-1 Alleles – AlphaNet

F: dysfunctional

  • Near normal level but doesn’t bind neutrophil elastase well
  • AAT levels may be normal in Alpha-1 involving the F
  • Likely lung risks like a Z
  • No liver accumulation
What is Your Phenotype and What Does it Mean?Kimberly Foil, MS, CGC, Genetic Counseling Program, Alpha-1 Foundation; Division of Pulmonary and Critical Care Medicine, Medical University of South Carolina (MUSC)